Clinical News

Antihypertensive therapy with an ARB is not associated with reductions in cardiovascular or all-cause mortality compared to non-ARB-based regimens in patients with type 2 diabetes, according to researchers at the Massachusetts College of Pharmacy and Health Sciences.

FDA announced recently that the injection form of Anzemet (dolasetron mesylate) should no longer be used to prevent chemotherapy-induced nausea and vomiting.

DHA supplementation doesn?t appear to slow the rate of cognitive and functional decline in individuals with mild to moderate Alzheimer?s disease, according to research published in the November 3 issue of the Journal of the American Medical Association, HealthDay News reported.

In a multi-national, placebo-controlled, double-blind trial, the selective vitamin D receptor activator paricalcitol (Zemplar, Abbott Laboratories), at doses of 1 µg or 2 µg daily, can reduce albuminuria in patients with type 2 diabetes, who were already being treated with renin-angiotensin-aldosterone system inhibitors.

"Few patients who are prescribed varenicline to assist in smoking cessation remain on the therapy, according to retrospective data presented during the 45th midyear meeting of the American Society of Health Systems Pharmacists."

Treatment of recurrent herpes simplex labialis with combination 5% acyclovir and 1% hydrocortisone cream is safe in adolescents. In a study of a 5-day treatment course, no safety concerns were identified, said Anders Strand, MD, PhD, at the 45th midyear meeting of the American Society of Health Systems Pharmacists.

Obesity was associated with worse overall and disease-free survival in women with operable breast cancer treated with adjuvant chemotherapy.

A newly approved drug, denosumab (Xgeva, Amgen), delays skeletal-related side effects for 5 months longer compared to zoledronic acid (Zometa and Reclast, Novartis) in patients with breast cancer and bone metastases, according to phase 3 trial results presented at the 33rd Annual CTRC-AACR San Antonio Breast Cancer Symposium.

A combination of lapatinib, trastuzumab, and paclitaxel significantly improved tumor response rates in patients with HER2-positive breast cancers, according to a new study presented at the San Antonio Breast Cancer Symposium held recently in San Antonio, Texas.

A medication for skeleton-related events in patients with bone metastases was shown to significantly improve bone metastasis-free survival rates in prostate cancer patients, according to a new trial.

FDA is recommending removing the breast cancer indication from the label for Avastin (bevacizumab) because the drug has not been shown to be safe and effective for that use.

FDA has approved Gardasil (Merck) for the prevention of anal cancer and associated precancerous lesions due to human papillomavirus (HPV) types 6, 11, 16, and 18 in individuals aged 9 through 26 years.

Diagnostic testing, narcotics, and questionable treatment modalities appear to be overused for chronic neck pain, while effective treatments such as therapeutic exercise appear to be underused, according to a study in the November issue of Arthritis Care & Research, HealthDay News reported.

FDA is recommending removing the breast cancer indication from the label for Avastin (bevacizumab) because the drug has not been shown to be safe and effective for that use.

Postmenopausal women who take aromatase inhibitors as a treatment for breast cancer may be at an increased risk for developing cardiovascular disease, according to a new study presented at the San Antonio Breast Cancer Symposium.

A recently released IOM workshop summary indicates there are myriad ideas, including better use of EMRs and research to focus action on the most common elements associated with adverse events.

Patients with health insurance are abandoning their prescriptions at higher rates than they did a year ago and far more frequently than they did 5 years ago, according to a recent study.

New data show that while nearly all MI patients receive beta blockers, most patients receive suboptimal doses that are never increased.

PainSAFE, an initiative of the American Pain Foundation, has launched a website to educate patients and practitioners about pain-management therapies and their risks.

At the Third Annual Risk Management and Drug Safety Summit, attendees and presenters discussed the latest issues related to risk and safety, and examined how REMS and drug safety have fared since 2007.

Johnson & Johnson announced another product recall, this one involving Children's Benadryl Allergy Fastmelt Tablets, Junior Strength Motrin Caplets, and Extra Strength Rolaids softchews, the Associated Press reported.

The majority of Americans and Canadians are getting enough vitamin D and calcium to meet their needs, according to a new report from the Institute of Medicine.

An FDA panel has recommended that the agency approve Orexigen Therapeutics? and Takeda?s obesity drug Contrave (naltrexone SR/bupropion SR). This makes the drug the first in a group of competitors to receive this recommendation, the Associated Press reported.

The National Community Pharmacists Association installed Robert Greenwood of Iowa as its new president during the organization?s 112th Annual Convention and Trade Exposition, held in October in Philadelphia.

A team of pharmacy students from Washington State University?s College of Pharmacy won the 2010 Good Neighbor Pharmacy National Community Pharmacists Association Pruitt-Schutte Student Business Plan Competition. The announcement was made during NCPA?s 112th Annual Convention and Trade Exposition in October in Philadelphia.

The National Association of State Controlled Substances Authorities (NASCSA) has received a $200,000 grant from Purdue Pharma LP, which it will distribute to state government agencies that are able to accept private funding specifically for their state prescription-monitoring programs. NASCSA will manage the solicitation, review, and funding of the grant proposals. Selection of recipients will be based on an independent review conducted by its Special Projects Committee, which consists of association members with expertise in the fields of prescription drug abuse and diversion, and prescription drug-monitoring programs. NASCSA expects to distribute the grants by the end of 2011. The grant is part of Purdue Pharma?s efforts to support the operation, expansion, and awareness of appropriately designed state prescription drug-monitoring programs.

McNeil Consumer Healthcare, a unit of Johnson & Johnson, is voluntarily recalling nearly 128,000 bottles of Tylenol 8-hour caplets after some consumers complained of a musty or moldy odor in the products, the company announced.

In this section we showcase products and product news that ran up against space limitations or fell outside the parameters of recently featured categories in the print edition. Look for more OTC Product News in upcoming issues of the Drug Topics e-newsletter.

With single-pill, fixed-dose combinations of antihypertensive agents, as well as triple-therapy, single-pill agents emerging, updated guidance on specific types of combination therapy for hypertension has emerged.

FDA is asking the manufacturers of gonadotropin-releasing hormone agonists to add new safety information to the Warnings and Precautions section of the drugs? labels about an increased risk of diabetes and certain cardiovascular diseases.