Neurology

Currently, systemic estrogen replacement therapy is contraindicated for women who have a history of ischemic stroke due to the risk of stroke recurrence.

DTC pharmacies offer significant savings on total medication costs for neurological drugs, but out-of-pocket expenses remain high for insured patients.

New research shows metformin's inconsistent neuroprotective effects against Alzheimer disease, challenging its role in diabetes management for cognitive health.

In this retrospective cohort study, researchers investigated the association between formulary coverage for disease-modifying therapies and the potential for MS relapse.

Community pharmacies emerge as key players in early cognitive decline detection, offering vital screening tools and support for at-risk patients.

Patients with a single cardiometabolic disease have an approximately 48% greater risk of developing all-cause dementia than those without a cardiometabolic disease.

In the study, the composition of the gut microbiome could also be affected by food insecurity, a known social determinant of health.

Researchers investigated Norwegian pharmacists to understand their expertise, and potential knowledge gaps, regarding issues of epilepsy and treatment using antiseizure medication.

PET and autopsy assays suggest that Alzheimer disease (AD) and non-AD tau pathologies could be the underlying cause of some late-life mood disorders.

Although there is no cure for MS, treatment focuses on recovery from attacks, reducing relapse, slowing disease progression, and managing multiple sclerosis symptoms.

Triptans are often a first-line treatment for migraine and can be used to treat menstrual migraine and cluster headaches.

However, there is no association between cortisol and tau pathology.

Dihydroergotamine (Brekiya) is an acute treatment to help relieve migraine attacks, and it can come in nasal sprays, injections, and intravenous infusions.

The drug is approved for the short-term treatment of acute repetitive seizures, also known as seizure clusters, which differ from a patient’s normal seizure pattern.

The drug is also approved for adults with chronic inflammatory demyelinating polyneuropathy.

Investigators find 5 distinct obesity trajectories that influenced brain morphology, function, and cognition.

Data from the HERCULES phase 3 trial were presented at the 2025 Annual Meeting for the American Academy of Neurology for non-relapsing secondary progressive multiple sclerosis.

Further studies are needed to further confirm the association between glucagon-like peptide 1 medication and reductions in dementia risk.

Previous research shows herpes zoster is associated with a higher long-term risk of subjective cognitive decline, with increased risk for men who carried APOE ε4.

Investigators found that zonisamide was associated with a reduction in monthly migraine days for pediatric populations.

Patients preferred ultrasound stimulation, followed by magnetic stimulation, drugs, electrical stimulation, and brain implantations.

The FDA also granted priority review, with a Prescription Drug User Fee Act target action date of August 19, 2025.

The tablet formation of risdiplam (Evrysdi) demonstrates bioequivalence to the oral formulation of the drug.

The designation is based on the AMULET phase 2 trial, which was the first-in-human study of the drug.

Data has shown the investigational cell therapy is well-tolerated in patients and showed preliminary impacts on cognition.