Clinical News

Implementation of a policy restricting drug sampling and pharmaceutical industry detailing in a small rural clinic resulted in modest reductions in the prescription of branded and promoted drugs, according to research published in the September/October issue of the "Annals of Family Medicine."

Use of Schedule II opioids, back pain, headache, and pre-existing substance use disorders are all associated with alcohol- or drug-related encounters and emergency department visits in adults who have taken prescribed opioids for at least 90 days, according to a study published in the Sept. 13 issue of the Archives of Internal Medicine, HealthDay News reports.

The National Institutes of Health?s National Institute on Drug Abuse awarded a 5-year, $3.7 million research grant to Jia Bei Wang, PhD, a professor of pharmaceutical sciences at The University of Maryland School of Pharmacy to develop a drug to treat cocaine addiction.

The updated International Society on Hypertension in Blacks consensus statement on the management of hypertension in this population places a major emphasis on comprehensive assessment and appropriate risk stratification of individual patients with hypertension, according to a report published online Oct. 4 in Hypertension and reported by HealthDay News.

Individuals with ocular herpes simplex virus treated with prophylactic oral antibiotics appear to be at a lower risk of recurrence of epithelial keratitis, stromal keratitis, conjunctivitis, and blepharitis, according to research published in the September issue of the Archives of Ophthalmology, HealthDay News reported.

Treatment of rheumatoid arthritis (RA) with disease-modifying antirheumatic drugs (DMARDs), glucocorticoids, biologics, or a combination of these agents significantly reduces radiographic evidence of joint destruction, with no advantage seen for patients whose treatment includes biologics, according to research published in the October issue of Arthritis & Rheumatism.

For women whose ovarian cancer has been in remission, restarting chemotherapy early on the basis of heightened serum CA125 concentration does not improve survival compared with postponing treatment until symptoms of relapse appear, according to a study published in the Oct. 2, cancer-themed issue of The Lancet.

FDA has issued warning letters to three companies that manufacture mouth-rinse products and market them with claims that they remove plaque above the gum line or promote healthy gums. These claims suggest the products are effective in preventing gum disease when no such benefit has been demonstrated.

FDA is requiring a labeling change and Medication Guide to warn patients and healthcare providers about the possible risk of atypical thigh-bone (femoral) fracture in patients who take bisphosphonates for the prevention and treatment of osteoporosis.

FDA's Cardiovascular and Renal Drugs Advisory Committee voted 9 to 0 on Sept. 20 in favor of approving dabigatran etexilate (Pradaxa) for stroke prevention in patients with atrial fibrillation.

Abbott is complying with FDA's request to withdraw sibutramine (Meridia) from the U.S. market because the obesity drug may pose unnecessary cardiovascular risks to patients, FDA announced.

FDA has requested that all companies that manufacture, distribute, and/or market unapproved single-ingredient oral colchicine, a medication commonly used for the daily prevention of gout, to treat acute gout flare-ups, and for the treatment of Familial Mediterranean Fever, stop manufacturing this drug.

Amgen and Johnson & Johnson are recalling certain lots of the anemia drugs Epogen and Procrit because vials of the injectable medicines might develop tiny glass flakes that could cause blood clots and other serious health problems.

Bristol-Myers Squibb Co. recalled 60 million tablets of the blood pressure medication Avalide (irbesartan-hydrochlorothiazide) in the United States and Puerto Rico.

FDA has approved the oral multiple sclerosis treatment fingolimod 0.5 mg, as a first-line treatment for relapsing forms of multiple sclerosis. The approval makes fingolimod the first oral treatment indicated for relapsing forms of MS available in the United States.

Erectile dysfunction (ED) drugs purchased online may be worse than useless. They could pose significant health risks.

The anticipated approval of Gardasil for women 27 to 45 years of age has thrown the issue of vaccine reimbursement for pharmacists into the spotlight.

FDA has determined to significantly restrict the use of formulations that contain rosiglitazone (Avandia, Avandamet, and Avandaryl, GlaxoSmithKline) to patients with Type 2 diabetes who cannot control their diabetes with other medications.

Abbott is complying with FDA's request to withdraw sibutramine (Meridia) from the U.S. market because the obesity drug may pose unnecessary cardiovascular (CV) risks to patients.

Thirty-nine states now have a tool to help pharmacists identify at least some questionable prescriptions and suggest when a patient may be doctor-shopping or pharmacy-shopping in order to obtain controlled substances. That tool is the state prescription monitoring program.

Community pharmacists face a "War on Drugs" different from the one heard about on the news. This war doesn't even seem to be on lawmakers' radar.

The Washington State Board of Pharmacy is revisiting its rules requiring pharmacists to dispense emergency contraceptives.

In a novel collaboration with PBM giant CVS Caremark and its specialty pharmacy Generation Health, PGXL Laboratories will use its expertise in anticoagulants to improve the quality of patient care through pharmacogenetic testing, physician education, and drug-specific software programs.

While genetic testing can identify patients who will be nonresponsive to certain drug therapies, it can also suggest other drugs as treatment options that might work. These may include pharmaceuticals not usually considered for treatment of a particular cancer.

FDA approved increasing the length of therapy with Valcyte (valganciclovir hydrochloride) in adult kidney-transplant patients at high risk for cytomegalovirus (CMV) disease, according to an Aug. 10 statement made by Genentech Inc.

Infections with the deadly methicillin-resistant Staphylococcus aureus (MRSA) bacteria contracted in hospitals and other healthcare settings have declined 28% over a 4-year period, according to a new Centers for Disease Control and Prevention (CDC) study of about 15 million people.

The National Association of Chain Drug Stores (NACDS) has developed a new resource to make the case for policies that improve medication adherence.

Calcium supplementation is associated with an increased risk of myocardial infarction (MI), according to a meta-analysis published online July 29 in BMJ and reported by HealthDay News.

Novartis Vaccines has started shipping the FDA-approved seasonal influenza vaccine Fluvirin to U.S. customers ahead of the 2010&endash;2011 season, allowing healthcare practitioners to initiate protection of their patients well in advance.

Certain lots of Advair Diskus (fluticasone propionate and salmeterol inhalation powder) inhalers that were stolen from a GlaxoSmithKline (GSK) distribution warehouse near Richmond, Va., in August 2009 have recently been found in some pharmacies, according to FDA.