October 24th 2024
Nina Vadiei, PharmD, BCPP, a clinical associate professor at UT Austin and a clinical pharmacy specialist in psychiatry at San Antonio State Hospital, discusses her career as a psychiatric pharmacist.
Research advancing on best leukemia regimens
November 6th 2006One of the benefits of using targeted therapies such as imatinib (Gleevec, Novartis) in treating cancer is that they seem to be fairly well tolerated. Indeed, it may be beneficial to investigate combining them with cytotoxic chemotherapy, or even other targeted therapies, to see if patients' clinical outcomes can be improved, said B. Douglas Smith, M.D., an assistant professor of oncology at the Johns Hopkins University School of Medicine in Baltimore.
Witnesses tell of deaths due to IVIG shortage
November 6th 2006A late September hearing saw patients and advocates telling the government that people are dying due to lack of access to intravenous immune globulin therapy (IVIG). It also recorded allegations about suspected artificial shortages, federal foot-dragging, and supplies directed to less-deserving patients. The "town hall" meeting, held recently in Arlington, Va., took five-minute statements from about three dozen witnesses as part of an independent study the Department of Health & Human Services (HHS) contracted for. Patients have been unable to get IVIG, get it in the best setting, or get the brand that works for them.
Changes and decisions facing beneficiaries
November 6th 2006Very few drug plan providers left the Medicare market in 2007, but their offerings have shifted. There are fewer plans offering basic coverage and more offering enhanced coverage. Beneficiaries in most states have 50-60 prescription drug plans to consider including 15 or 16 that offer partial or complete coverage in the donut hole.
Cardinal issues instructions for using SE infusion pumps
October 23rd 2006Notwithstanding its concerns about the safety of Alaris SE infusion pumps, the Food & Drug Administration is not requiring manufacturer Cardinal Health to recall the 140,000 pumps in use in thousands of hospitals around the country.
New software helps track and locate missing drugs
October 23rd 2006Tracking and locating lost medications is a chronic problem for many hospitals. When a medication gets lost, there are so many different places it can be, including the several different drop-off points along the way before a drug reaches a patient.
New tacks to reduce outpatient chemo errors
October 23rd 2006Tracking medication errors in an inpatient hospital setting is fairly common. But what about errors that occur when patients self-administer, or when parents administer drugs to their children at home? Who checks to see if patients are being compliant, or if prescribing errors have been made? Did the family members who are charged with dispensing to children understand the instructions? Or are they doing things doctors and pharmacists are not expecting them to?
FDA examines strategies to improve drug safety
October 23rd 2006While the Food & Drug Administration has always been deeply concerned with drug safety, the organization is taking new and improved measures to pay closer attention to this issue, said Scott Gottlieb, M.D., Deputy Commissioner for Medical and Scientific Affairs at FDA.
Drug-eluting coronary stents benefit MI patients
October 23rd 2006In some patients with acute myocardial infarction (MI), the use of sirolimus (Rapamune, Wyeth)-eluting stents drastically reduced the rate of in-stent restenosis at one year, compared with uncoated, bare-metal stents, according to the results of a new study.
Clinical Twisters: Fixing therapeutic non-compliance
October 23rd 2006A 63-year-old Hispanic man, P.C., seen in your diabetes clinic, is complaining of burning and aching in his legs and feet. His current daily drugs include glipizide ER (Glucotrol XL, Pfizer) 10 mg, pioglitazone (Actos, Takeda) 45 mg, metformin ER (Glucophage XR, Bristol-Myers Squibb) 500 mg, escitalopram (Lexapro, Forest) 10 mg, atorvastatin (Lipitor, Pfizer) 40 mg, ezetimibe (Zetia, Merck/ Schering-Plough) 10 mg , aspirin 325 mg, and ramipril 10 mg. Although his current fasting blood glucose is 100, his A1c=9. Upon questioning him, you find he has not been taking his medicine regularly since he lost his job and insurance last spring. What do you recommend?
World Congress of Cardiology trials focus on RAS agents
October 23rd 2006The 2006 World Congress of Cardiology (WCC) was host to more than 25,000 cardiologists this year. Noteworthy among the thousands of presentations were several large-scale drug trials, most of which evaluated agents affecting the renin-angiotensin system (RAS).
Heparin overdoses bring changes
October 23rd 2006Medication safety experts nationwide were dismayed but not surprised upon hearing the tragic news that three premature infants died after receiving a fatal dose of heparin at Methodist Hospital in Indianapolis. Three other pediatric patients who also received inappropriate doses of heparin were transferred to Riley Hospital for Children in Indianapolis where they were reported to be in critical condition at press time.
R.Ph.s can help reduce incidence of induced labor
October 9th 2006Through-the-roof liability costs are convincing many hospitals to take measures to limit induced labor and the use of associated drugs, particularly the hormone oxytocin. "Inducing labor before 39 weeks places both mother and child at increased risk," said Kathy Connolly, assistant VP of risk management at Premier Inc., an alliance of 1,500 nonprofit hospitals.
R.Ph.s can help reduce incidence of induced labor
October 9th 2006Through-the-roof liability costs are convincing many hospitals to take measures to limit induced labor and the use of associated drugs, particularly the hormone oxytocin. "Inducing labor before 39 weeks places both mother and child at increased risk," said Kathy Connolly, assistant VP of risk management at Premier Inc., an alliance of 1,500 nonprofit hospitals.
Pediatric deaths bring hospital unwanted attention
October 9th 2006The entire pediatrics program at Stony Brook University Hospital in Suffolk County, N.Y., has recently come under scrutiny following the deaths of three children there between May and July of this year. On Aug. 14, the New York State Department of Health issued a cease-and-desist order against the hospital's pediatric cardiac surgery and catheterization programs, and on Aug. 18, the health department fined the hospital the maximum amount of $38,000 for 19 violations associated with these fatalities. An administrative court hearing at which the hospital may challenge the cease-and-desist order was scheduled for Sept. 28.
Field tests planned for automated syringe system
September 18th 2006Intelligent Hospital Systems plans to release within a year-into two North American hospitals-a machine capable of filling intravenous bags and syringes. The Canadian medical device company said final testing of its Robotic IV Automation System (RIVA) was scheduled to begin in August. If testing goes as planned, the system will be ready for use at Winnipeg's St. Boniface General Hospital in early November.
New Pharma knowledge base streamlines CPOE
September 18th 2006Although computerized physician order entry (CPOE) offers the potential to save lives and reduce medical costs, it hasn't yet garnered widespread acceptance. According to the results of a questionnaire administered in a study by Harvey Murff, M.D., of Brigham & Women's Hospital in Boston and Joseph Kannry, M.D., of Mount Sinai-NYU Health Systems in New York, published in the Journal of the American Medical Informatics Association, one of the biggest obstacles to acceptance is the difficulty of executing tasks "in a straightforward manner." Physicians find it takes longer to type prescriptions into the system than it does to write prescriptions on a pad in the traditional way.
Field tests planned for automated syringe system
September 18th 2006Intelligent Hospital Systems plans to release within a year-into two North American hospitals-a machine capable of filling intravenous bags and syringes. The Canadian medical device company said final testing of its Robotic IV Automation System (RIVA) was scheduled to begin in August. If testing goes as planned, the system will be ready for use at Winnipeg's St. Boniface General Hospital in early November.
Task force issues report on safe sedation practices
September 18th 2006Almost 70% of minor surgeries are now performed in surgical centers, physicians' offices, and hospital outpatient departments. Procedures including cardiac catheterizations and colonoscopies can be done using sedatives such as midazolam and fentanyl instead of general anesthesia.
ASCO updates guidelines on use of CSFs
September 18th 2006The American Society of Clinical Oncology (ASCO) recently updated its guidelines for the use of hematopoietic colony-stimulating factors (CSFs). The 2005 update committee unanimously agreed that the reduction in febrile neutropenia (FN) was an important clinical outcome that justified the use of CSFs, regardless of impact on other factors, when the risk of FN was approximately 20% and no other equally effective regimen that did not require CSFs was available. The first guidelines were published in 1994, and they were updated in 1996, 1997, 2000, and, most recently, 2005.
Cancer expert decries rising drug costs
September 18th 2006Can society countenance paying $161,000 a year for treating one cancer patient, as was estimated for one new drug? And again and again for many patients? If newer agents cost 500 times the older ones, can we cover them? What if, due to new agents, some cancers become more like other chronic diseases, where expensive treatment continues for a lifetime?
JCAHO seeks hospitals to test psychiatric measures
September 18th 2006The Joint Commission on Accreditation of Healthcare Organizations is looking for a few good hospitals. A few good psychiatric hospitals, that is. JCAHO is rolling out its first-ever hospital-based performance measures for inpatient psychiatric care for a year-long trial run starting in January 2007. Final measures will be released in October 2008.
Pharmacist intervention benefits diabetic patients
September 18th 2006Data from a new study funded in part by the Agency for Healthcare Research & Quality (AHRQ) revealed a robust reduction in patients' blood sugar levels when pharmacists or nurses were utilized as case managers who made independent decisions regarding medication use instead of waiting for physician approval.
Can performance measures ignite antibiotic resistance?
September 4th 2006Pneumonia is a disease that accounts for greater than 750,000 hospitalizations in Americans 65 years of age and older, with a mortality rate of approximately 7% and 12% within 30 days of onset. Since the late 1990s, the National Pneumonia Project of the Centers for Medicare & Medicaid Services has promoted hospital practices associated with improved outcomes, one of which is antibiotic administration within a specified time of hospital admission. CMS, along with other organizations, uses this as a performance measure and currently recommends that patients with pneumonia receive antibiotics within four hours of arrival at the hospital.
Chemo guidelines expose new risks, raise awareness
September 4th 2006ASHP's revised guidelines on the handling of hazardous pharmaceuticals could not have come at a more opportune time. As chemotherapy agents become more powerful and chemotherapy administration shifts from the inpatient setting to physician offices and infusion centers, controlling occupational exposure to hazardous drugs has taken on a new urgency.