Physicians will soon have a fourth-generation fluoroquinolone with dual activity against bacteria to treat persons with community-acquired respiratory infections. The FDA recently approved gemifloxacin (Factive, GeneSoft Pharmaceuticals) for the treatment of acute bacterial exacerbation of chronic bronchitis (AECB) caused by Streptococcus pneumoniae, Haemophilus influenzae, Haemophilus parainfluenzae, or Moraxella catarrhalis and community-acquired pneumonia (CAP) of mild-to-moderate severity caused by S. pneumoniae (including penicillin-resistant strains), H. influenzae, M. catarrhalis, Mycoplasma pneumoniae, Chlamydia pneumoniae, or Klebsiella pneumoniae. Gemifloxacin will be available in pharmacies by the end of the year.
Targeted Drug Combination Reveals New Activity in Brain Tumors
December 28th 2021A combination of two targeted cancer drugs showed unprecedented, “clinically meaningful” activity in patients with highly malignant brain tumors that carried a rare genetic mutation, according to a clinical trial report by investigators from Dana-Farber Cancer Institute.