Finerenone for Heart Failure and Kidney Disease Associated With Type 2 Diabetes
The FDA has approved finerenone (Kerendia, Bayer) for the treatment of adults with chronic kidney disease (CKD) associated with type 2 diabetes.
The FDA has approved finerenone (Kerendia, Bayer) for the treatment of adults
with chronic kidney disease (CKD) associated with type 2 diabetes.1 Finerenone is a nonsteroidal selective mineralocorticoid receptor (MR) antagonist used to reduce the risk of sustained estimated glomerular filtration rate (eGFR) decline, endstage
kidney disease, cardiovascular death, nonfatal myocardial infarction, and hospitalization for heart failure.1,2
Finerenone is activated by aldosterone and cortisol, and it also regulates gene transcription. Finerenone works by blocking MR-mediated sodium reabsorption
and MR overactivation in epithelial and nonepithelial tissues. Finerenone has high potency and selectivity for the MR.
Glycemic Control Among Patients With Diabetes Worsened Over Past Decade
February 27th 2025Authors of a research letter published in JAMA said that the decrease in glycemic control may be due to consequences of the COVID-19 pandemic, such as sedentary behavior and increased mental health stressors.
